University Lyon-1
Lyon University Hospital (“Hospices Civils de Lyon”)
Bank of Tissues and Cells
CarMeN Laboratory (INSERM 1060)
Phone: +33-4-72-11-76-67
Mail:serge.nataf@inserm.fr
since 2011: Senior manager at the department of Cell Therapy and Tissue Engineering of the University Hospital of Lyon (HCL)
2002-2011: Head of the research group “Macrophages/microglia in neurodegenerative disorders”, INSERM Unit U811, Lyon. Senior assistant manager at the biology resource Center of the University Hospital of Lyon (HCL)
2000-2002: Post-doctoral fellow in the INSERM unit U433 (Neuropathology and Experimental Neurobiology), University of Lyon
1996-2000: Post-doctoral fellow in the laboratory of Prof. Scott Barnum (Role of the complement system in CNS disorders), University of Alabama at Birmingham, Alabama, USA
1994-1996: PhD student, INSERM U298 “Neurobiology and Immunopathology of Neurodegenerative Diseases” University of Angers, France
1990-1994: Medical Internship, Department of Neurology, University of Nantes, France
ACADEMIC QUALIFICATIONS
2011: Professor of Cytology and Histology, Lyon school of Medicine, University of Lyon, France
2007: Accreditation to supervise research, University of Lyon-1, France
2002: Associate Professor of Cytology and Histology, Lyon school of Medicine, University of Lyon, France
1996: Ph.D. in Immunopathology, University of Nantes, France
1994: Medical doctor degree and accreditation in Neurology, University of Nantes, France
ACADEMIC TASKS
Academic Editor of PLoS ONE since 2011
Co-founder and board member of French Club of Neuro-immunology (CFNI) since 2011
Head of the department of Cytology and Histology at the Lyon school of medicine, University of Lyon since 2011
CURRENT RESEARCH INTERESTS
Adipose stem cells to treat neuro-inflammatory conditions
Multiple sclerosis pathophysiology
Neuroimmunoinformatics
LIST OF 10 SELECTED PUBLICATIONS
1. Nataf S and Pays L. Gene co-expression analysis unravels a link between C9orf72 and RNA metabolism in myeloid cells. Acta Neuropathol Commun 2015. Oct 15;3:64
2. Nataf S. The sensory immune system: a neural twist to the antigenic discontinuity theory. Nat Rev Immunol. 2014 Apr;14(4):280.
3. Lieury A, Chanal M, Androdias G, Reynolds R, Cavagna S, Giraudon P, Confavreux C, Nataf S. Tissue remodeling in periplaque regions of multiple sclerosis spinal cord lesions. Glia 2014. Oct;62(10):1645-58.
4. Androdias G., Reynolds R., Chanal M., Ritleng C., Confavreux C andNataf S. Meningeal T-cells associate with diffuse axonal loss in multiple sclerosis. Ann. Neurol. 2010 Oct;68(4):465-76
5. Davoust N., Vuaillat C., Androdias G., Nataf S. From bone marrow to microglia: barriers and avenues. (2008) Trends Immunol. 2008 29:227-34.
6. Davoust N., Vuaillat C., Cavillon G., Domenget C., Hatterer E., Bernard A., Dumontel C., Jurdic P., Macus C., Confavreux C., Belin MF., Nataf S. Bone marrow CD34+/B220+ progenitors target the inflamed brain and display in vitro differentiation potential toward microglia. FASEB J. 2006 Oct;20(12):2081-92
7. Hatterer E., Davoust N., Didier-BAzes M., Vuaillat C., Malcus C., Belin MF., Nataf S. How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 2006 Jan 15;107(2):806-12
8. Nataf S., Carroll SL., Wetsel RA., Szalai AJ., Barnum SR. Attenuation of experimental autoimmune demyelination in complement-deficient mice. J Immunol. 2000 Nov 15;165(10):5867-73
9. Nataf S., Stahel PF., Davoust N., Barnum SR. Complement anaphylatoxin receptors on neurons: new tricks for old receptors?Trends neurosci. 1999 Sep;22(9):397-402. Review.
10. Nataf S., Davoust N., Ames B and Barnum SR. Human T-cells express the C5aR and are chemoattracted to C5a. J Immunol. 1999 162: 4018-4023