• Professor Translational Immunology and Cell Biology

    molecular cell biology and immunology

    Research at the crossroad of state-of-the-art laboratory clinic
    Interested in working as a professor in the Netherlands? Click here for more information

     
  • IBRO-UM5

     

    Advanced School on Neuroimmunology and Brain Infections

    Rabat, Morocco | November 21 - December 4, 2017

    Read more ...  
  • Postdoctoral Research Fellow in Australia

    Apply for a position as a Postdoctoral Research Fellow at the University of Queensland in Brisbane, Australia. 

    Read more ...  
  • AAT-AD/PD 2018

    15 - 18 March in Turin, Italy

    Read more ...  
  • CUBANNI 2017 - report

    CUBANNI 2017

    Read more ...  
  • ESOC 2018 - 4th European Stroke Organisation Conference

    ESOC 2018
    The 4th European STroke Organisation Conference

    16 - 18 May, 2018
    Gothenburg, Sweden

    Read more ...  

Klein

 

 

Professor
Departments of Internal Medicine, Pathology & Immunology, Neuroscience
Director, Center for Neuroimmunology and Neuroinfectious Diseases
Associate Director, Medical Scientists Training Program
Washington University School of Medicine - St. Louis

 

 

 

Dr. Robyn S. Klein received her M.D. and Ph.D. degrees from Albert Einstein College of Medicine. She then completed her internship and residency in Internal Medicine at the Brigham & Women's Hospital, Harvard University and her fellowship in Infectious Diseases and post-doctoral training in Immunology at the Massachusetts General Hospital, Harvard University. Dr. Klein joined the Washington University School of Medicine in 2003, where she developed a neuroimmunology basic and translational science research program focused on the pathogenesis of neuroinflammatory diseases of the central nervous system (CNS). Studies in the Klein laboratory focus on cellular and molecular mechanisms that orchestrate inflammation during both viral and autoimmune encephalitides via endothelial-immune cell interactions. The experimental approach involves the development of in vitro models of the blood-brain barrier to study the CNS entry of WNV, mononuclear cells, and of the signaling responses that regulate vascular permeability. Studies using in vivo models for both autoimmune and WNV encephalitides focus on identifying the localizing cues that control leukocyte entry and persistent inflammation. Work over the past few years has defined novel roles for cytokines and chemokines in the regulation of blood-brain barrier permeability to protective versus pathogenic leukocytes, and to West Nile virus (WNV), a positive strand flavivirus that may enter the CNS and cause encephalitis. These inflammatory cues also regulate CNS repair by neural stem cells (NSCs) in mice with viral infection or demyelinating diseases. Aspects related to NSC-mediated repair include defining the localizing, proliferative and differentiation cues that lead to successful repair of damaged neurons and myelin. These studies will advance our understanding of normal CNS immune surveillance and its relationship to the wide range in inflammatory patterns observed in various neuroinflammatory diseases. This information will also lead to the identification of novel therapeutic targets, which is much needed in an era where there is little to offer patients with these diseases.

Joomla Template by Joomla51.com

This website or its third party tools use cookies, which are necessary to its functioning and required to achieve the purposes illustrated in the cookie policy. If you want to know more or withdraw your consent to all or some of the cookies, please refer to the cookie policy. By closing this banner, scrolling this page, clicking a link or continuing to browse otherwise, you agree to the use of cookies. To find out more about the cookies we use and how to delete them, see our Cookie policy