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Battistini

 

 

Head of Research
Head Neuroimmunology Unit
Santa Lucia Foundation Scientific Institute

 

 

Positions and Emplyment
1989-1990 Medical Officer, Italian Army, Ministry of Defence, Italy
1990-1994 Neurology Resident, University of Rome “La Sapienza”, Rome, Italy
1990-1992 Research Fellow, Institute of Neurobiology, National Research Council (C.N.R.), Rome, Italy. Mentors: Prof. Rita Levi-Montalcini and Prof. Pietro Calissano.
1993-1995 Research Fellow, Dept. of Neuropathology, Albert Einstein College of Medicine, Bronx, NY, USA. Mentors: Prof. Celia F. Brosnan and Prof. Cedric S. Raine.
1995-1997 Research Associate, Biochemistry Department, E.K. Srhiver Center, Waltham, MA, USA. Mentor: Prof. Marjorie B. Lees.
1995-1997 Instructor of Neurology (Junior Faculty), Harvard Medical School, Boston, MA, USA.
1997-2005 Visiting Professor, Dept. of Neuropathology, Albert Einstein College of Medicine, Bronx, NY, USA.
1997-1999 Head of the Neuroimmunology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) Santa Lucia Foundation, Rome, Italy.
2000-present Head of the Neuroimmunology Unit and Co-Head of the Flow Cytometry Unit (Permanent Faculty Level), Istituto di Ricovero e Cura a Carattere Scientifico (I.R.C.C.S.) Santa Lucia Foundation, Rome, Italy.

Awards and Fellowships
1993 Fellowship from the Italian Government (M.U.R.S.T. Program for research training in USA)
1994 Recipient of a short-term Fellowship from the Italian Multiple Sclerosis Society (A.I.S.M.)
1995-1997 Recipient of a long-term Fellowship from the National Multiple Sclerosis Society (N.M.S.S.)
2002 Rita Levi Montalcini Award for the “Best Young Scientist” in the MS field from the Italian Multiple Sclerosis Society (A.I.S.M.)
2013 National Habilitation as Full Professor for 06/D6 Neurology and 05/F1 Applied Biology.

Large-scale Project Coordination
2005-2007 National coordinator of Project “Malattie neurodegenerative. Meccanismi immunologici e sinaptici del danno neurodegenerativo in corso di Sclerosi Multipla e Sclerosi Multipla Sperimentale”. Italian Ministry of Health.
2015-2018 National coordinator of Project “Does gut flora influence autoimmune responses in Multiple Sclerosis? The MAIT cell story”. Italian Ministry of Health.

Teaching activities
1995-1996 Instructor of Neurology, Harvard Medical School, MA, Boston, USA.
2000-present Professor of Neuroimmunology, University of Rome “Tor Vergata”, Italy.

Editorial activities
Ad hoc reviewer for Immunity, Annals of Neurology, Brain, Blood, J. Immunol., Journal of Leukocyte Biology, Eur. J. Immunol., Plos Pathogens, Hepatology, Plos One, Multiple Sclerosis, J Neuroimmunology, Immunology, Clinical Immunology, Journal of Neurological Sciences, Neuroscience.

External Reviewer
Evaluator of grant applications for: Italian (AISM/FISM) and UK-MS Society, Human Frontier Science Program (HFSP), Agence Nationale de la Recherche, (ANR), Italian Ministry of Education, University and Research (MIUR), Italian Ministry of Health.

Scientific Committees
2012-present Member of the Scientific Board of the Italian Multiple Sclerosis Foundation (FISM)
2016-present Member of the Scientific Board of the International Society NeuroImmunology (ISNI)

Scientific Societies membership
1989-present Member of the Italian Society of Neurology (SIN)
1993-present Member of the American Academy of Neurology (AAN)
1993-present Member of the International Society of Neuroimmunology (ISNI)
1997-present Member of the Italian Society of Immunology (SII)
1998-present Founder of the Italian Society of Neuroimmunology (AINI)
2006-2008 Member of AINI Advisory Board

Patents
Publication number: EP1501505 (A1) Publication date: 2005-02-02 Battistini L., Borsellino G., De santis R., Carminati P. “ Use of 3-(2-ethylphenyl)-S-methoxy-1H-1,2,4-triazole for the treatment of autoimmune diseases “WO2818-101
European Patent Application No. 04 745 177.8 – 2404 Battistini L. Borsellino G., Diamantini A. “Use of multiparametric flow cytometry for the diagnosis, prognosis and immunotherapy validation of autoimmune and oncohematologic disorders “

Congress organization
Chairman of the Scientific Commettee, Workshop “Pathogenic and Regulatory Cells in Demyelinating Diseases”. Rome, 12-15 September 1999.
Chairman of the Organizing Commettee, VII International Congress, International Society of Neuroimmunology (ISNI). Venice (Italy), September 2004.

Last 5 years selected peer-reviewed publications
(Selected from 105 peer-reviewed publications.)

1: Chiurchiù V, Leuti A, Dalli J, Jacobsson A, Battistini L, Maccarrone M, Serhan CN. Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses. Sci Transl Med. 2016 Aug 24;8(353):353ra111.
2: Volpe E., Sambucci M., Battistini L., Borsellino G. Fas–Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis. Front. Immunol., 27 September 2016
3: Chiurchiù V, Leuti A, Cencioni MT, Albanese M, De Bardi M, Bisogno T, Centonze D, Battistini L, Maccarrone M. Modulation of monocytes by bioactive lipid anandamide in multiple sclerosis involves distinct Toll-like receptors. Pharmacol Res. 2016 Sep 8;113(Pt A):313-319.
4: Gentile A, Musella A, Bullitta S, Fresegna D, De Vito F, Fantozzi R, Piras E, Gargano F, Borsellino G, Battistini L, Schubart A, Mandolesi G, Centonze D. Siponimod (BAF312) prevents synaptic neurodegeneration in experimental multiple sclerosis. .J Neuroinflammation. 2016 Aug 26;13(1):207.
5: Volpe E, Battistini L, Borsellino G. Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis. Mediators Inflamm. 2015;2015:475158.
6: Di Mitri D, Sambucci M, Loiarro M, De Bardi M, Volpe E, Cencioni MT, Gasperini C, Centonze D, Sette C, Akbar AN, Borsellino G, Battistini L. The p38 mitogen-activated protein kinase cascade modulates T helper type 17 differentiation and functionality in multiple sclerosis. Immunology. 2015 Oct;146(2):251-63.
7: Cencioni MT, Santini S, Ruocco G, Borsellino G, De Bardi M, Grasso MG, Ruggieri S, Gasperini C, Centonze D, Barilá D, Battistini L, Volpe E. FAS-ligand regulates differential activation-induced cell death of human T-helper 1 and 17 cells in healthy donors and multiple sclerosis patients. Cell Death Dis. 2015 May 7;6:e1741
8: Mechelli R., Manzari C., Policano C., Annese A., Picardi E., Umeton R., Fornasiero A., D'Erchia A.M., Buscarinu M.C., Agliardi C., Annibali V., Serafini B., Rosicarelli B., Romano S., Angelini D.F., Ricigliano V.A.G., Buttari F., Battistini L., Centonze D., Guerini F.R., D'Alfonso S., Pesole G., Salvetti M., and Ristori G. Epstein-Barr virus genetic variants are associated with multiple sclerosis. NEUROLOGY, Neurology. 2015 Mar 31;84(13):1362-8.
9: Angelini DF, Ottone T, Guerrera G, Lavorgna S, Cittadini M, Buccisano F, De Bardi M, Gargano F, Maurillo L, Divona M, Noguera NI, Consalvo MI, Borsellino G, Bernardi G, Amadori S, Venditti A, Battistini L, Lo-Coco F. A Leukemia-Associated CD34/CD123/CD25/CD99+ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia. Clin Cancer Res. 2015 Sep 1;21(17):3977-85.
10: Ruocco G, Rossi S, Motta C, Macchiarulo G, Barbieri F, De Bardi M, Borsellino G, Finardi A, Grasso MG, Ruggieri S, Gasperini C, Furlan R, Centonze D, Battistini L, Volpe E. T helper 9 cells induced by plasmacytoid dendritic cells regulate interleukin-17 in multiple sclerosis. Clin Sci (Lond). 2015 Aug;129(4):291-303.
11: Rossi S, Motta C, Studer V, Macchiarulo G, Volpe E, Barbieri F, Ruocco G, Buttari F, Finardi A, Mancino R, Weiss S, Battistini L, Martino G, Furlan R, Drulovic J, Centonze D. Interleukin-1β causes excitotoxic neurodegeneration and multiple sclerosis disease progression by activating the apoptotic protein p53. Mol Neurodegener. 2014 Dec 12;9:56.
12: Chiurchiù V, Battistini L, Maccarrone M. Endocannabinoid signaling in innate and adaptive immunity. Immunology. 2015 Jan 14. doi: 10.1111/imm.12441. [Epub ahead of print]
13: Chiurchiù V, Lanuti M, De Bardi M, Battistini L, Maccarrone M. The differential characterization of GPR55 receptor in human peripheral blood reveals a distinctive expression in monocytes and NK cells and a proinflammatory role in these innate cells. Int Immunol. 2014 Oct 25. pii: dxu097. [Epub ahead of print]
14: Camperio C, Muscolini M, Volpe E, Di Mitri D, Mechelli R, Buscarinu MC, Ruggieri S, Piccolella E, Salvetti M, Gasperini C, Battistini L, Tuosto L. CD28 ligation in the absence of TCR stimulation up-regulates IL-17A and pro-inflammatory cytokines in relapsing-remitting multiple sclerosis T lymphocytes. Immunol Lett. 2014 Mar-Apr;158(1-2):134-42.
15: Loiarro M, Volpe E, Ruggiero V, Gallo G, Furlan R, Maiorino C, Battistini L, Sette C. Mutational analysis identifies residues crucial for homodimerization of myeloid differentiation factor 88 (MyD88) and for its function in immune cells. J Biol Chem. 2013 Oct 18;288(42):30210-22.
16: Picozza M, Battistini L, Borsellino G. Mononuclear phagocytes and marker modulation: when CD16 disappears, CD38 takes the stage. Blood. 2013 Jul 18;122(3):456-7.
17: Abrahamsson SV, Angelini DF, Dubinsky AN, Morel E, Oh U, Jones JL, Carassiti D, Reynolds R, Salvetti M, Calabresi PA, Coles AJ, Battistini L, Martin R, Burt RK, Muraro PA. Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis. Brain. 2013 Sep;136(Pt 9):2888-903.
18: Angelini DF, Serafini B, Piras E, Severa M, Coccia EM, Rosicarelli B, Ruggieri S, Gasperini C, Buttari F, Centonze D, Mechelli R, Salvetti M, Borsellino G, Aloisi F, Battistini L. Increased CD8+ T cell response to Epstein-Barr virus lytic antigens in the active phase of multiple sclerosis. PLoS Pathog. 2013;9(4):e1003220
19: Mozzetta C, Consalvi S, Saccone V, Tierney M, Diamantini A, Mitchell KJ, Marazzi G, Borsellino G, Battistini L, Sassoon D, Sacco A, Puri PL. Fibroadipogenic progenitors mediate the ability of HDAC inhibitors to promote regeneration in dystrophic muscles of young, but not old Mdx mice. EMBO Mol Med. 2013 Apr;5(4):626-39.
20: Chiurchiù V, Cencioni MT, Bisicchia E, De Bardi M, Gasperini C, Borsellino G, Centonze D, Battistini L, Maccarrone M. Distinct modulation of human myeloid and plasmacytoid dendritic cells by anandamide in multiple sclerosis. Ann Neurol. 2013 May;73(5):626-36.
21: Bisicchia E, Chiurchiù V, Viscomi MT, Latini L, Fezza F, Battistini L, Maccarrone M, Molinari M. Activation of type-2 cannabinoid receptor inhibits neuroprotective and antiinflammatory actions of glucocorticoid receptor α: when one is better than two. Cell Mol Life Sci. 2013 Jun;70(12):2191-204.
22: Noguera NI, Song MS, Divona M, Catalano G, Calvo KL, García F, Ottone T, Florenzano F, Faraoni I, Battistini L, Colombo E, Amadori S, Pandolfi PP, Lo-Coco F. Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia. Leukemia. 2013 Apr;27(5):1037-43.
23: Coscia M, Vitale C, Peola S, Foglietta M, Rigoni M, Griggio V, Castella B, Angelini D, Chiaretti S, Riganti C, Guarini A, Drandi D, Ladetto M, Bosia A, Foà R, Battistini L, Boccadoro M, Fournié JJ, Massaia M. Dysfunctional Vγ9Vδ2 T cells are negative prognosticators and markers of dysregulated mevalonate pathway activity in chronic lymphocytic leukemia cells. Blood. 2012 Oct 18;120(16):3271-9.
24: Sancesario GM, Cencioni MT, Esposito Z, Borsellino G, Nuccetelli M, Martoran A, Battistini L, Sorge R, Spalletta G, Ferrazzoli D, Bernardi G, Bernardini S, Sancesario G. The load of amyloid-β oligomers is decreased in the cerebrospinal fluid of Alzheimer's disease patients. J Alzheimers Dis. 2012;31(4):865-78.
25: Rossi S, Motta C, Studer V, Monteleone F, De Chiara V, Buttari F, Barbieri F, Bernardi G, Battistini L, Cutter G, Stüve O, Salvetti M, Centonze D. A genetic variant of the anti-apoptotic protein Akt predicts natalizumab-induced lymphocytosis and post-natalizumab multiple sclerosis reactivation. Mult Scler. 2013 Jan;19(1):59-68.
26: Rossi S, Furlan R, De Chiara V, Motta C, Studer V, Mori F, Musella A, Bergami A, Muzio L, Bernardi G, Battistini L, Martino G, Centonze D. Interleukin-1β causes synaptic hyperexcitability in multiple sclerosis. Ann Neurol. 2012 Jan;71(1):76-83.
27: D'Alessandro A, D'Aguanno S, Cencioni MT, Pieroni L, Diamantini A, Battistini L, Longone P, Spalloni A, De Laurenzi V, Bernardini S, Federici G, Urbani A. Protein repertoire impact of Ubiquitin-Proteasome System impairment: insight into the protective role of beta-estradiol. J Proteomics. 2012 Feb 2;75(4):1440-53.
28: Canino C, Mori F, Cambria A, Diamantini A, Germoni S, Alessandrini G, Borsellino G, Galati R, Battistini L, Blandino R, Facciolo F, Citro G, Strano S, Muti P, Blandino G, Cioce M. SASP mediates chemoresistance and tumor-initiating-activity of mesothelioma cells. Oncogene. 2012 Jun 28;31(26):3148-63
29: Di Mitri D, Azevedo RI, Henson SM, Libri V, Riddell NE, Macaulay R, KiplingD, Soares MV, Battistini L, Akbar AN. Reversible senescence in human CD4+CD45RA+CD27- memory T cells. J Immunol. 2011 Sep 1;187(5):2093-100.
30: Dalla Libera D, Di Mitri D, Bergami A, Centonze D, Gasperini C, Grasso MG, Galgani S, Martinelli V, Comi G, Avolio C, Martino G, Borsellino G, Sallusto F, Battistini L, Furlan R. T regulatory cells are markers of disease activity in multiple sclerosis patients. PLoS One. 2011;6(6):e21386.
31: Placido R, Auricchio G, Gabriele I, Galli E, Brunetti E, Colizzi V, Battistini L, Mancino G. Characterization of the immune response of human cord-blood derived gamma/delta T cells to stimulation with aminobisphosphonate compounds. Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):101-10
32: Annibali V, Ristori G, Angelini DF, Serafini B, Mechelli R, Cannoni S, Romano S, Paolillo A, Abderrahim H, Diamantini A, Borsellino G, Aloisi F, Battistini L, Salvetti M. CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis. Brain. 2011 Feb;134(Pt 2):542-54.
33: Libri V, Azevedo RI, Jackson SE, Di Mitri D, Lachmann R, Fuhrmann S, Vukmanovic-Stejic M, Yong K, Battistini L, Kern F, Soares MV, Akbar AN. Cytomegalovirus infection induces the accumulation of short-lived, multifunctional CD4+CD45RA+CD27+ T cells: the potential involvement of interleukin-7 in this process. Immunology. 2011 Mar;132(3):326-39.
34: D'Amelio M, Cavallucci V, Middei S, Marchetti C, Pacioni S, Ferri A, Diamantini A, De Zio D, Carrara P, Battistini L, Moreno S, Bacci A, Ammassari-Teule M, Marie H, Cecconi F. Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease. Nat Neurosci. 2011 Jan;14(1):69-76.
35: Esposito M, Ruffini F, Bergami A, Garzetti L, Borsellino G, Battistini L, Martino G, Furlan R. IL-17- and IFN-γ-secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity. J Immunol. 2010 Dec 15;185(12):7467-73.
36: Angelini DF, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, Poccia F, Semenzato G, Borsellino G, Santoni A, Battistini L. NKG2A inhibits NKG2C effector functions of γδ T cells: implications in health and disease. J Leukoc Biol. 2011 Jan;89(1):75-84.

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